四合一痛覺測試系統包含電子von Frey測痛儀、鼠爪壓力測量儀、鼠爪腫脹測量儀、抓力測量儀四套電子痛覺測量儀用四種方法完成對大鼠小鼠等動物的痛覺。

• Electronic von Frey Anesthesiometer 電子von Frey測痛儀

• Randall Selitto test Paw Pressure Test Meter 鼠爪壓力測量儀

• Plethysmometer, Paw Volume Meter or Paw Edema Meter鼠爪腫脹測量儀

• Grip Strength Meter Mice and Rats 抓力測量儀

型號2390型+2500型+520MR型+2200型

電子觸覺閾疼痛閾測量儀機械痛閾測量儀Von Frey系統簡單易用。用來替代傳統的Von Frey Hairs纖毛機械刺激針（Von Frey Hairs）.不僅可以Von Frey test測試機械痛閾或觸覺閾測量還可以測試疼痛閾值。它使研究者可以自動記錄機械痛閾和觸覺閾測量。操作簡單精確設計緊湊。

電子Von Frey測痛儀的主要特點

? 適用MRI探針

? 單體內可插入三個探針

? LCD 顯示屏 (Floating or last max. & minimum) 

? 硬槍頭能達 800 Gr. 

? “Supertips™” 從15 到65Gr. 

? 適用1K探針

? 電子微處理器0.1Gr插入式探針

? 可選的模擬輸出線

? 吸頭可根據情況定制

? 具有測量、存儲和顯示功能免除了手算的繁瑣。

? 可以預設和選擇大限額能精確到1g當到預設的限額時警示燈會通知使用人員。

? 實驗簡便選擇合適的原件放在探針上插進實驗對象根據實驗對象的反應儀器就能快速的顯示出結果并儲存。

? 作為核心原件的內置傳感器固定在元件上并和電子系統相連以便記錄數據。所有的電子測痛儀已在出廠前校準完畢不再需要購買任何的校準設備。

鼠爪壓力測痛儀 Randall&Selitto測試通過逐步提高作用于動物爪子上的機械壓力逼近動物的疼痛閾限測量并記錄動物產生逃避反應時的瞬間大壓力以測定動物機械鈍痛的痛覺閾限。

與熱痛不同鼠爪壓力疼痛測痛儀用于機械壓痛和鈍痛的痛覺測量常用于辨別左右爪不同的痛覺反應多涉及脊髓神經過程人工辨別動物縮腿反應并用踏板控制馬達的起止。

鼠爪壓力疼痛測試儀的主要特點 

? 適用于大鼠和小鼠

? 精確度為0.1克大壓力400克

? 數字顯示功能

? 配置腳踏控制器

? RS-232輸出

鼠爪體積測量儀用來衡量消炎藥的有效性。使用時講大鼠、小鼠的爪子浸入含有特殊細胞的水中由于浸泡水的壓力發生了變化。壓力的變化會被校準并顯示在特殊的電子監視器上。這種檢測形式可以消除由于重復浸入發生導電性的改變而產生的改變這種情況在類似的其他儀器上發現過。測試結果直接顯示在LCD上（大鼠精確到0.01毫升、小鼠精確到0.001毫升）。無論是用電池還是用9V或12V的適配器該設備表現穩定操作安全。

鼠爪腫脹測定儀的主要特點 

? 無需潤濕液可消除由于重復浸入發生導電性的改變而產生的體積誤差 

? 配備90°角的全透明亞克力操作支架可進行清晰方便

? 維護方便不需要特殊的護理液

? 數據準確不需要每次使用校準每年僅需校正一次

? 具有內置電源實現停電不間斷操作

? 帶LCD顯示器讀書方便

? 體積精確度0.01ml（大鼠）0.001ml（小鼠）

鼠抓力測量儀可用于小鼠或大鼠系統測試的使大鼠或小鼠釋放的抓力。常用于藥物、毒物、肌肉松弛藥、衰老、神經損傷對肌力的影響。將大鼠或小鼠置于有機玻璃平臺上在抓力吊架前面。嚙齒動物會本能地抓取任何東西以嘗試去停止這種被動的反向運動這將會持續抓吊臺直到牽力克服了抓力為止。動物失去其抓力后力峰值前級放大器會自動地儲存峰值的抓力并顯示在液晶板上。

大小鼠抓力測量儀的主要特點

? 拉力傳感器大力度值≥1500g 

? 大力可允許超過數值≥150g

? 讀數精度為0.1g

? 配備有基座、金屬套桿和傳感器Hub

? 配大小鼠網格和T形桿

? 陽極電鍍處理的面板并配備有固定吸盤

? 配備36g砝碼校準模塊

? 數據采集器自帶電源可供數據采集器時間≥250小時

? 帶Clear清零鍵使用方便

Our newest addition to our Analgesia line can perform the Electronic von Frey, Digital Randall Selitto, Plethysmometer and Grip Strength Meter test with one electronic system.

Order any one of the test systems complete and the only additional item(s) needed are the individual modules to perform each test.

Electronics has up to three inputs allowing users to perform four very different tests with one electronic system when studies call for doing so.

All data is stored and displayed in the electronics supplied.

Example: 
Order any one of the 2390 Series Electronic von Frey systems; add on either or both the Digital Paw Pressure Applicator only and/or the glass stａnd setup only and you have a system that is complete for all three individual tests.

A wonderful addition to any laboratory facility studying analgesic compounds in research.

Stａnd and animal sling for Randall Selitto test sold separay.

部分參考文獻

[HTML] An electronic pressure-meter nociception paw test for mice

TM Cunha, WA Verri Jr, GG Vivancos… - Brazilian Journal of …, 2004 - SciELO Brasil

... an inflammatory process and sensitized the paws of mice with different doses of carrageenin
ａnd prostaglandin E 2 (PGE 2 ... consisted of a hand-held force transducer fitted with a 0.5 mm
2 polypropylene tip (electronic von Frey anesthesiometer, IITC Inc., Life ...

[HTML] Pharmacological characterisation of a rat model of incisional pain

GT Whiteside, J Harrison, J Boulet… - British journal of …, 2004 - Wiley Online Library

... Pharma, Neuropharmacology, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA E-mailgarth ... Issue
published online2 FEB 2009; Article first published online2 FEB 2009; ... previously described
in this modeltactile allodynia using an automated electronic von Frey (IITC, CA, USA ...

Pharmacological characterization of the chronic constriction injury model of neuropathic pain

J De Vry, E Kuhl, P Franken-Kunkel, G Eckel - European journal of …, 2004 - Elsevier

... 4 December 2003 Revised 1 March 2004 Accepted 25 March 2004 Available online 10 May
2004. Abstract. ... Mechanical allodynia was measured by means of a pressure transducer (electronic
von Frey Anaesthesiometer, IITC-Life Science Instruments, Woodlａnd Hills, CA). ...

Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

EJ Rahn, AM Zvonok, GA Thakur, AD Khanolkar… - … of Pharmacology and …, 2008 - ASPET

... E-mailahohmann{at}uga.edu. Next Section. Abstract. ... Mechanical withdrawal thresholds were
assessed using a digital electronic von Frey anesthesiometer (IITC model Alemo 2290-4; IITC
Life Sciences Inc., Woodlａnd Hills, CA) equipped with a rigid tip. ...

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, …

KJ Valenzano, L Tafesse, G Lee, JE Harrison… - …, 2005 - Elsevier

... 2004 Revised 26 November 2004 Accepted 10 December 2004 Available online 19 February ...
The marble-burying behavior model of anxiety (Njung'e ａnd Handley, 1990 ... noxious tactile stimulus
(VWT) were determined using an automated electronic von Frey apparatus (IITC ...

Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats

F Li, IG Obrosova, O Abatan, D Tian… - American Journal of …, 2005 - Am Physiological Soc

... Digital sensory NCV (SNCV) was recorded in the digital nerve to the second toe by stimulating
with a square ... by quantifying the withdrawal threshold of the hindpaw in response to mechanical
stimulation using a von Frey anesthesiometer (model 2290C; IITC Life Science ...

Activation of presynaptic NMDA receptors coupled to NaV1. 8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization

CA Parada, GG Vivancos, CH Tambeli… - Proceedings of the …, 2003 - National Acad Sciences

... Intrathecal administration of prostaglandin E 2 (PGE 2 ), glutamate, and NMDA causes a bilateral
long-lasting mechanical paw hypernociception ... reflex with a hand-held force transducer adapted
with a 0.5-mm 2 polypropylene tip (electronic von Frey hair; IITC Life Science ...

The use of an electronic von Frey device for evaluation of sensory threshold in neurologically normal dogs and those with acute spinal cord injury

SA Moore, BF Hettlich, A Waln - The Veterinary Journal, 2013 - Elsevier

... Accepted 3 November 2012 Available online 13 December 2012. Abstract. The ...
examination. von Frey device. The electronic von Frey device (IITC Life Science)
consisted of a load cell, handle, recording device and tip (Fig. 1 ...